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Status

Click here for the latest status, as of May 14, 2012.


New directions in research: watch the clip of our new, live webinar from World AIDS Day (Dec. 1, 2011) or read Volume 10 of our FightAIDS@Home Newsletter, posted October 21, 2011. You can watch the videos from our live webcast from last year's World AIDS Day (Dec. 1, 2010), as well, for additional background information. You can also read the archived editions of FightAIDS@Home News: Volume 1, Volume 2, Volume 3, Volume 4, Volume 5, Volume 6, Volume 7, Volume 8, and Volume 9. You can read about some of our previous results in the Journal of Chemical Information and Modelling.

Go to battle against AIDS with your computer!


Fight AIDS at Home "What is FightAIDS@Home?"







FightAIDS@Home is the first biomedical distributed computing project ever launched. It is
run by the Olson Laboratory at The Scripps Research Institute in La Jolla, California. We provide free software that you download and install. The software uses your computer's idle cycles to assist fundamental research in discovering new drugs, building on our growing knowledge of the structural biology of AIDS. In addition, this research helps us study the mechanisms of multi-drug-resistance that the "super bugs" of HIV use to escape the current anti-AIDS drugs. And this research helps us create, test, refine, and share the tools and protocols that thousands of other labs use in their research against other diseases.

FightAIDS@Home joined World Community Grid
November 2005

FightAIDS@Home, which has been run independently by the Olson Laboratory since 2002, joined the World Community Grid on November 21, 2005. The World Community Grid is a public distributed-computing infrastructure devoted to running projects that will benefit humanity.

In September of 2009, FightAIDS@Home received its 100,000th CPU year from the World Community Grid! Thank you all very much for performing these calculations that help us advance the global struggle against HIV/AIDS!!!

World Community Grid is making technology available only to public and not-for-profit organizations to use in humanitarian research that might otherwise not be completed due to the high cost of the computer infrastructure required in the absence of a public grid. IBM Corporation has donated the hardware, software, technical services and expertise to build the infrastructure for World Community Grid and provides free hosting, maintenance and support. We are grateful that the World Community Grid has invited FightAIDS@Home to join their effort.

The FightAIDS@Home client that was inherited from Entropia was not ideal for both the FightAIDS@Home members and the Olson Laboratory. Several features of the Entropia environment were not functional since we took over Entropia's side of the project, and newer versions of the AutoDock code could not be implemented in the system.



The transition to World Community Grid has improved FightAIDS@Home in important ways.

  • it has provided FightAIDS@Home Members with information about their contribution to the project, including the number of job credits they have computed, as well as overall project statistics.
  • it has provided 3D graphical output showing computational progress.
  • it has provided a forum for FightAIDS@Home discussion and updates.
  • it has provided a maintainable and updateable environment for AutoDock and the science run on FightAIDS@Home.
  • it has and will continue to help increase awareness of the FightAIDS@Home project, enabling us to run more advanced computations.
  • it has added support of FightAIDS@Home for both Linux and Mac OS X-based systems.


Fight AIDS at Home "Getting Started"

To start running FightAIDS@Home on World Community Grid, please go to the updated how to join page, or go directly to the World Community Grid Website.


Note that there is more than one humanitarian project running on the World Community Grid. The default setting for a new member on World Community Grid is to contribute computing power to all of the projects. You may select to contribute only to FightAIDS@Home by editing your profile by going to My Grid on the website for World Community Grid. The My Projects page will allow you to opt-in and out of projects ( by default, you are opted-in to all current projects). For more details information about the process see the how to join page.

Changes to your project selections will take place the next time your computer finishes its current piece of work and returns the result to World Community Grid.



For detailed descriptions of the experiments we perform on FightAIDS@Home, please check the "Status page".

Results of these FightAIDS@Home experiments, in the form of unprocessed AutoDock dlg files, are available to the public upon request. For further information, e-mail Dr. Alex L. Perryman: perryman ]~[ scripps . edu (replace ]~[ with the @ symbol and remove the spaces). Please include the phrase "FAAH data" in the subject line of your e-mail. Since the amount of data is on the order of many terabytes, you will need to provide suitable media (such as external hard drives) for receiving a copy of these results.

The AutoDock input files ("pdbqt" files) that we generated for several of the ZINC-derived libraries of compounds that we use in the virtual screens on FightAIDS@Home are now available for free at http://zinc.docking.org/pdbqt/.

After achieving some very promising preliminary results, in June, 2011, we submitted a proposal to IBM to create a new project on World Community Grid. To learn more about it, read the Citizen IBM blog post called "I'll Take 'Curing Malaria' for $1,000, Alex". This project, which was launched on World Community Grid's 7th birthday (Nov. 16, 2011), is called the "Global Online Fight Against Malaria" (GO Fight Against Malaria). Would you like to help us fight malaria, as well as HIV/AIDS? If you do want to help, then CLICK HERE to register and join World Community Grid. You can learn more at our new TSRI site for the GO Fight Against Malaria project.







Molecular art on HIV protease above created by Dr. Stefano Forli.

Last modified: 5/14/2012 by Dr. Alex L. Perryman

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